Lobular Breast Cancer and E-cadherin loss

Using the causal event of E-cadherin loss as a starting point, we study how ILC cells control anchorage independence, their cell cycle regulation, and invasive and metastatic phenotype. We ultimately aim at translation of our results into daily pathological diagnosis and treatment.
Over the past 20 years, our work has helped to lay a biochemical foundation for two clinical phase II intervention trials in ILC.  
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The Oncogenic Tyrosine Kinase FER

In high grade cancers such as Triple Negative Breast Cancer and Head & Neck cancer, FER is a late progression factor promoting multiple oncogenic events through the control over endosomal sorting and recycling. Furthermore, FER has revealed itself as a predictive factor for Taxane benefit in high rist Breast Cancer. Clinical conformation efforts are currently ongoing using retrospective and new prospective trial data.
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