NEWS NEWS NEWS NEWS NEWS
Eline and Thijmen published a new mouse mode for inducible skin and mammary cancer based on conditional knockout of E-cadherin and p53 based on LGR6 expression in NEOPLASIA. Work sponsored by a consortium grant from the European Union H2020-FET (Mechanocontrol) (NOVEMBER 2022) |
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Eline and Elvira published data in the Journal of Pathology showing that R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer!
A fruitful collaboration with the John Hilkens group @ NKI/AvL . (NOVEMBER 2022) |
Them Id2 Boys Max Rätze and Thijs Koorman have figured out (well, at least in part) why ILC is a low grade disease! Work instigated by lab alumnus Robert van de Ven has culminated in a publication in Oncogene.
Take home message: E-cadherin loss leads to direct p120/Kaiso dependent transcriptional activation of Id2. Cytosolic Id2 binds and inhibits phosphorylation of Rb by CDK4/6, leading to dampening of cell cycle progression and a full arrest in anchorage independent conditions. Implications for CDK4/6 inhibitors in ILC? Keep following our work on this website and Twitter (@pwbderksen). Work was sponsored by NWO-VIDI, H2020-FET Mechanocontrol and KWF10456 (May 2022) |
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Sandra Tavares' Paper on FER kinase, its control over fast endosomal recycling and predictive value in breast cancer is out now in Cell Reports! Work Sponsored by KWF, NWO-TOP and H2020-Mechanocontrol. (April 2022) |
Thijs Koorman's LOXL3 paper is out in Oncogene! Uncoupling Collagen-I bundling from stiffness shows that ductal breast cancer cells, in contrast to ILC, use Loxl3 to spatially stiffen the ECM for collective invasion. Work produced within the H2020-FET project MECHANOCONTROL. (March 2022) |
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Christgen et al. are at it again! Cover art in the Journal of Pathology accompanying the Monumental inter-observer study showing that E-cadherin expression should be used as a standard to diagnose Lobular Breast Cancer. An absolute no-brainer that should be Globally implemented! (February 2022) |
OUT NOW! In the context of a special edition on Lobular Breast Cancer in Cancers, the end-all be-all review on ILC histology! (August 2021) |
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Matthias Christgen's paper on P-cadherin Switching in Lobular Breast Cancer With Tubular Elements is out in Modern Pathology! We co-author on this work, which shows that P-cadherin expression occurs in a subset of ILCs. P-cadherin is the molecular determinant of a mixed-appearing histomorphology in ILBCs with tubular elements. (June 2020) |
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Our COST Action LOBSTERPOT initiative got granted !! A financial boost that will support an unprecedented ELBCC-instigated oncology task force for more insight, understanding and cure for invasive lobular breast cancer (ILC).
See the details on the ELBCC website and sign up if you want to join this at the EU COST Portal for our action (CA19138). Follow @ELBCC on twitter using #LOBSTERPOT and #CA19138. (April 2020) |
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The European Lobular Breast Cancer (ELBCC) is live!
Go check out our brand-new Consortium website at www.elbcc.org!. ELBCC is focussed on understanding and treating Lobular Breast Cancer, by joining forces from the top Lobular Breast Cancer Labs and Hospitals in Europe. (May 2019) |
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WE'RE ON A ROLL!!! What a week!
Breast Cancer Now awarded us with a CATALYST grant (€580K) for preclinical lobular breast cancer trials and KWF 2018-II funded our new basic research project on invasive Head & Neck cancer and the tumor micro-environment (€672K)!! Yes, that's a whopping €1.25M to the DerksenLab! Good times. (January 2019) |
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Based on a joint KWF project with the Coffer lab, Vervoort et al. now report their excellent work on a novel role for SOX4 in tumor-induced angiogenesis in eLIFE !! Check out the data here.
(December 2018)
Our paper with the Brunton Lab on lobular breast cancer is now available: https://rdcu.be/9wmC.
We have used a combination of cell systems, patient data and preclinical mouse models to show that all lobular breast cancer (ILC) patients
may benefit from the PI3K/AKT-targeting drugs, regardless of their genetic make-up!
Let's pave the way for pharmacological inhibition of PI3K/AKT signals in PIK3CA non-mutant ILC!
(October 2018)
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We just published review in the Journal of Cell Science on treatment developments that are focused on mimicking the function of the BH3-only proteins to induce apoptosis, and consider their applicability in restoring normal apoptotic responses in anchorage-independent disseminating tumor cells. You can find this review by Clara van Oudenaarden here. (August 2018) |
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Karin Jansen just published a paper from her PhD work at the Koenderink lab in the Biophysical Journal!! This excellent piece of work demonstrates how Collagen architecture controls mechanics. You can find the paper here.
(June 2018)
From the paper:
E-cadherin (green) expression in αE-catenin kcock-down breast cancer cells
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Jolien's manuscript is now published by the Journal of Pathology !!
In this paper we show some pretty compelling evidence that loss of αE-catenin underpins E-cadherin expressing Invasive Lobular Breast Cancer. Click here for the Epub ahead of print. (May 2018) |
The Lord lab has published a new and exciting finding in collaboration with our lab showing that Lobular Breast Cancer depends on active Ros1 and are susceptible to Crizotinib inhibition!
Click here for the paper @CancerDiscovery
(April 2018)
Click here for the paper @CancerDiscovery
(April 2018)
We published a comprehensive review on how FOXO transcription factors control tumors together with the next door Burgering lab. Marten Hornsveld went all-out, an effort you can find here.
(December 2017)
(December 2017)
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Elvira Bakker has been awarded an Innovational Research Incentives Scheme VENI grant from NWO,
AND
a Young Investigator Grant from KWF!!
This personal award and prestigious grant will allow her to start her group as independent PI in our lab!!
Her research will focus on how R-Spondins drive breast cancer.
(August-2017)
AND
a Young Investigator Grant from KWF!!
This personal award and prestigious grant will allow her to start her group as independent PI in our lab!!
Her research will focus on how R-Spondins drive breast cancer.
(August-2017)
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We published Jolien's paper on prophylactic intraductal intervention of hereditary breast cancer in Oncotarget !
Caution is warranted for future clininal prevention trials: our studies in mice show that despite successful inhibition of breast cancer formation, intraductal cisplatin administration causes systemic tumor formation after long latency periods. You can find the PDF for this paper on our output page, and an Editorial in Ageing here. (July-2017) |
Our views on what makes E-cadherin mutant cancer 'tick' from a biochemical point of view and options for future clinical intervention are published in this week's
Cold Spring Harbor Perspectives in Biology Review Series.
You can also find the paper on our output page.
(May-2017)
Cold Spring Harbor Perspectives in Biology Review Series.
You can also find the paper on our output page.
(May-2017)
Sandra Published her paper entitled
"Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells"
in Nature Communications!!
You can find the pdf for this paper (research was done during her PhD at the Janody lab) at Nature.com.
(May-2017)
"Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells"
in Nature Communications!!
You can find the pdf for this paper (research was done during her PhD at the Janody lab) at Nature.com.
(May-2017)
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DerksenLab ran 10K for TEAM KWF!
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!! Team KWF raised 126K€ for our Research on FER Kinase !!
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Our collaborative NWO-TOP grant proposal with the Akhmanova and Klumperman labs has been funded !!!
This grant worth 675K€ will help us to study how microtubule dynamics and vesicular transport contribute to cancer cell metastasis.
(Feb-2017)
This grant worth 675K€ will help us to study how microtubule dynamics and vesicular transport contribute to cancer cell metastasis.
(Feb-2017)
Nature Communications has published Roberts paper on p120, cytokinesis and cancer aneuploidy!!!
"p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis."
You can find the pdf for this paper at Nature.com or at our output page.
(Dec-2016)
"p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis."
You can find the pdf for this paper at Nature.com or at our output page.
(Dec-2016)
KWF has funded our 2016 research proposal!
This grant worth 610K€ will enable us to functionally address how genetic lesions other that E-cadherin inactivation contribute to ILC tumor development and progression. We will perform research together with the lab of Edwin Cuppen
(Dec-2016)
This grant worth 610K€ will enable us to functionally address how genetic lesions other that E-cadherin inactivation contribute to ILC tumor development and progression. We will perform research together with the lab of Edwin Cuppen
(Dec-2016)
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Developmental Cell just published our collaborative paper with
Ben Bouchet and Anna Akhmanova! "Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1" In this paper, findings are presented that are based on a project from the Akhmanova lab. We have performed the in vivo experiments in mouse models of breast cancer. Check out the on-line ePub here. (Nov-2016) |
October is Breast Cancer Month! Our joint ERC-FET grant with the De Rooij lab was high-lighted at the UMC Utrecht.
RTV Utrecht broadcasted an interview about this grant (download the interview).
RTV Utrecht broadcasted an interview about this grant (download the interview).
Together wilt the lab of Johan de Rooij, our lab has received a Horizon 2020 grant worth 2.3M€!
In this consortium-based H2020-FET proposal we will study how breast cancer cells connect to the microenvironment and use those connections to metastasize.
(Aug-2016)
In this consortium-based H2020-FET proposal we will study how breast cancer cells connect to the microenvironment and use those connections to metastasize.
(Aug-2016)
KWF has chosen our research into FER kinase as their "Pet" project, which means that Derksenlab.org is one of the Ambassadors and Team KWF members during the Utrecht Marathon (March 19, 2017). Some of our lab members are going to run 10K during this event to support cancer research and cancer treatment. Check out this happening here.
(May-2016)
(May-2016)
This site was updated in November 2022
